![]() During follow-up, 11 patients dropped out (six in the study group and five in the control group), leaving 28 eyes in 28 patients for analysis (13 in the study group and 15 in the control group). The main outcome measurements included logMAR visual acuity and central foveal thickness (CFT) before surgery and at 3, 6, 9, and 12Â months after vitrectomy. This study was designed as a prospective, randomized, multicenter study comparing 19 eyes of 19 patients who received 150 units of kallidinogenase administered a day for 52Â weeks from the day after vitrectomy (study group) with 20 eyes of 20 patients who received no kallidinogenase (control group). To evaluate the effectiveness of the combination of vitrectomy with kallidinogenase for diabetic macular edema (DME). Yoshizumi, Yuki Ohara, Zaigen Tabuchi, Hitoshi Sumino, Hitomi Maeda, Yukiko Mochizuki, Hideki Yamane, Ken Kiuchi, Yoshiaki Seven of the BINs formed in this study appear to represent undescribed taxa, suggesting that even in this relatively well-studied family, much additional work remains before a comprehensive understanding of the diversity and evolutionary relationships for the Onychoteuthidae can be achieved.Effects of kallidinogenase in patients undergoing vitrectomy for diabetic macular edema. No sequences were available for five additional known species, making the total family diversity likely to exceed 34 species. Results support monophyly for the family and all seven onychoteuthid genera (including Moroteuthopsis, established herein as the senior genus name for species formerly attributed to Kondakovia) 29 genetically distinct species were recovered, with the BIN (Barcode Index Number) analysis for COI showing good congruence overall with morphological species groupings. In the present study, over 250 sequences of cytochrome c oxidase subunit I (COI) and 16S rRNA for 222 individuals were analysed to create a combined phylogeny for the family. The oegopsid squid family Onychoteuthidae was recently revised based on morphology, but sufficient material for a complementary molecular analysis has not been available until now. ![]()
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